Published On: Mon, Oct 1st, 2012

Bronchial Asthma : Treatment and Drugs

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How to treat ?

The for Asthma is based on the frequency and severity of the Asthma attacks.

Symptomatic treatment can be given for asthma as in the case of cough. The is the main target organ of many diseases including infections, malignancy, occupational diseases and rheumatological diseases. Some like amiodarone and methotrexate adversely affect the pulmonary interstitium. Heart failure may lead to pulmonary oedema. Thromboembolic diseases and pulmonary hypertension affect the pulmonary circulation.

Treatment for Asthma includes the following Classes of Drugs:

The person who is susceptible to Asthma should avoid the allergens and triggers and he should be away from them. He should improve the ventilation of the living areas and he can use air conditioning.

Bronchodilators:

Short acting beta-adrenergic receptor activators acts as bronchodilators. Bronchodilators can be administered as required in the form of a nebuliser solution by using a metered dispenser or it may be injected sub-cutaneously. Bronchodilators dilate the bronchioles and prevent the bronchoconstriction. They do not prevent the inflammatory response. Examples:- Albuterol, Terbutaline

Xanthine Drugs:

Xanthine drugs cause bronchodilation and inhibit the late phase of Asthma. These drugs are administered orally as second line drugs in combination with other therapies like with steroids. Example:- Theophylline. Theophylline have significant , cardiovascular and gastrointestinal side effects, this limits the overall usefulness of the theophylline.

Anti-inflammatory Drugs:

Corticosteroids are the anti-inflammatory drugs. These steroids are administered orally or by inhalation to blunt the inflammatory response of the Asthma. The long term oral use of corticosteroids may produce significant adverse effects that includes immunosuppression, increases susceptibility to the infections, osteoporosis and also shows effects on other hormones like glucocorticoids.

Cromolyn Sodium:

Cromolyn sodium is an anti-inflammatory agent that inhibits both the early and late stages of the Asthma. Its mechanism of action involves the mast cell function or its response to allergens.

Leukotriene Modifiers:

These are the new class of agents that blocks the synthesis of inflammatory mediators named as leukotrienes. Examples:- Zafirlukast

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