Antibe Therapeutics completes patient enrollment in OA knee pain trial for ATB-346

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Antibe Therapeutics, a Canadian pharma company has completed enrollment of patients in a phase 2B dose-ranging, efficacy clinical trial of its lead drug candidate ATB-346 for its use in reducing osteoarthritis (OA) pain.

The mid-stage clinical study will assess the effectiveness of ATB-346 in the reduction of OA knee pain in comparison to placebo in 360 patients.

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According to Antibe Therapeutics, the final patients will be subject to treatment for a couple of weeks, followed by a monitoring period of two weeks and analysis of the primary endpoint data.

The primary endpoint in the phase 2B is the variation in OA knee pain of ATB-346 compared to placebo as measured by the WOMAC subscale pain score, which is considered to be the gold standard in pain assessment for arthritis trials.

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Patients have been randomly grouped to receive placebo or one 150 mg, 200 mg or 250 mg of ATB-346 given daily.

Antibe Therapeutics expects to release top-line results of the ATB-346 clinical trial within six weeks.

ATB-346, which releases hydrogen sulfide, is derived from naproxen.

Antibe Therapeutics completes patient enrollment in OA knee pain trial for ATB-346

Antibe Therapeutics completes patient enrollment in OA knee pain trial for ATB-346

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